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Longitudinal course of symptom severity and fluctuation in patients with treatment-resistant unipolar and bipolar depression.

Abstract:

Little is currently known about the long-term course of symptom severity and fluctuation in patients with treatment-resistant depression (TRD). We assessed this using the longitudinal interval follow-up evaluation in 115 patients with TRD (84 unipolar, 31 bipolar) with 1-7 years (median 36 months) of follow-up. Of the follow-up months, 39.2% were spent asymptomatic and 21.1% at sub-threshold symptom level, while 15.8% were spent at mild, 13.9% at moderate, and 10.0% at severe depressive episo...

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Journal:
Psychiatry research
Volume:
207
Issue:
3
Pages:
143-149
Publication date:
2013-05-01
DOI:
EISSN:
1872-7123
ISSN:
0165-1781
Source identifiers:
390652

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