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Reduced placental protein 13 (PP13) in placental derived syncytiotrophoblast extracellular vesicles in preeclampsia: A novel tool to study the impaired cargo transmission of the placenta to the maternal organs

Abstract:
Introduction Placental syncytiotrophoblast (STB) release extracellular vesicles (STB-EVs) that communicate physiological and pathological placental signals to the maternal organs. STB-EV release also increases in preeclampsia (PE). Here we explored the cargo of PP13 in STB-EVs from PE versus control placentas. Methods Placentae were harvested following cesarean section deliveries, and dual placental lobe perfusion was used to harvest STB-EV. Maternal side pe... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1016/j.placenta.2018.04.013

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Womens & Reproductive Health
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Womens & Reproductive Health
Sharabi-Nov, A More by this author
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Grant:
ASPRE project (601852)
Publisher:
Elsevier Publisher's website
Journal:
Placenta Journal website
Volume:
66
Pages:
17-25
Publication date:
2018-04-25
Acceptance date:
2018-04-23
DOI:
ISSN:
0143-4004
Pubs id:
pubs:853786
URN:
uri:960e7963-f127-411b-919d-b65b24872cf9
UUID:
uuid:960e7963-f127-411b-919d-b65b24872cf9
Local pid:
pubs:853786

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