Favorable Outcome Following Sotrovimab Monoclonal Antibody in a Patient with Prolonged SARS-CoV-2 Omicron Infection with HIV/AIDS

Journal article

Persistent viral shedding or prolonged coronavirus disease 2019 (COVID-19) symptom is one of unresolved problem in immunocompromised individuals. We herein report an HIV/AIDS patient with Pneumocystis jirovecii pneumonia and prolonged COVID-19, possibly due to immune reconstitution inflammatory syndrome. His viral shedding and COVID-19 symptoms persisted for 39 days but were promptly resolved following sotrovimab monoclonal antibody therapy. This case suggests that prolonged COVID-19 and persistent viral shedding due to severe cellular immunodeficiency can occur in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) omicron infection and that sotrovimab is effective in the treatment of prolonged COVID-19 caused by omicron/BA.1.

Authors: Adachi, E; Saito, M; Koga, M; Tsutsumi, T; Yotsuyanagi, H

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Japanese Society of Internal Medicine
• Journal: Internal Medicine
• Volume: 61
• Issue: 22
• Pages: 3459-3462
• Article number: 0485-22
• Publication date: 2022-09-05
• DOI: 10.2169/internalmedicine.0485-22
• ISSN: 0918-2918
• Language: English
• Keywords: Internal medicine; Antibody; Pneumonia; Coronavirus disease 2019 (COVID-19); Medicine; Disease; 2019-20 coronavirus outbreak; Immunology; Immune system; Virology; Infectious disease (medical specialty); Outbreak; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Viral shedding; Monoclonal antibody; Coronavirus