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The effects of rod and cone loss on the photic regulation of locomotor activity and heart rate.

Abstract:

Behavioral responses to light indirectly affect cardiovascular output, but in anesthetized rodents a direct effect of light on heart rate has also been described. Both the basis for this response and the contribution of rods, cones and melanopsin-based photosensitive retinal ganglion cells (pRGCs) remains unknown. To understand how light acutely regulates heart rate we studied responses to light in mice lacking all rod and cone photoreceptors (rd/rd cl ) along with wild-type controls. Our ini...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
Journal:
European journal of neuroscience
Volume:
28
Issue:
4
Pages:
724-729
Publication date:
2008-08-01
DOI:
EISSN:
1460-9568
ISSN:
0953-816X
Source identifiers:
101269
Language:
English
Keywords:
Pubs id:
pubs:101269
UUID:
uuid:95d47a42-de82-4207-99e0-857d48708a1d
Local pid:
pubs:101269
Deposit date:
2012-12-19

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