Biochemical kinetics model of DSB repair and induction of gamma-H2AX foci by non-homologous end joining.

Journal article

We developed a biochemical kinetics approach to describe the repair of double-strand breaks (DSBs) produced by low-LET radiation by modeling molecular events associated with non-homologous end joining (NHEJ). A system of coupled nonlinear ordinary differential equations describes the induction of DSBs and activation pathways for major NHEJ components including Ku70/80, DNA-PKcs, and the ligase IV-XRCC4 heterodimer. The autophosphorylation of DNA-PKcs and subsequent induction of gamma-H2AX foc...

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Authors: Cucinotta, F; Pluth, J; Anderson, J; Harper, J; O'Neill, P

• Publication status: Published
• Journal: Radiation research
• Volume: 169
• Issue: 2
• Pages: 214-222
• Publication date: 2008-02-01
• DOI: 10.1667/rr1035.1
• EISSN: 1938-5404
• ISSN: 0033-7587
• Language: English
• Keywords: Biochemistry; Humans; Models, Genetic; Models, Chemical; Kinetics; Computer Simulation; Histones; DNA Repair; DNA Breaks, Double-Stranded; DNA