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Biochemical kinetics model of DSB repair and induction of gamma-H2AX foci by non-homologous end joining.

Abstract:

We developed a biochemical kinetics approach to describe the repair of double-strand breaks (DSBs) produced by low-LET radiation by modeling molecular events associated with non-homologous end joining (NHEJ). A system of coupled nonlinear ordinary differential equations describes the induction of DSBs and activation pathways for major NHEJ components including Ku70/80, DNA-PKcs, and the ligase IV-XRCC4 heterodimer. The autophosphorylation of DNA-PKcs and subsequent induction of gamma-H2AX foc...

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Publication status:
Published

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Publisher copy:
10.1667/rr1035.1

Authors


Cucinotta, FA More by this author
Anderson, JA More by this author
Harper, JV More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Journal:
Radiation research
Volume:
169
Issue:
2
Pages:
214-222
Publication date:
2008-02-05
DOI:
EISSN:
1938-5404
ISSN:
0033-7587
URN:
uuid:95cda7d0-f70d-44e1-bb62-b9c477d2ca2d
Source identifiers:
311028
Local pid:
pubs:311028

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