Journal article
Photocatalytic late-stage functionalization of sulfonamides via sulfonyl radical intermediates
- Abstract:
- A plethora of drug molecules and agrochemicals contain the sulfonamide functional group. However, sulfonamides are seldom viewed as synthetically useful functional groups. To confront this limitation, a late-stage functionalization strategy is described, which allows sulfonamides to be converted to pivotal sulfonyl radical intermediates. This methodology exploits a metal-free photocatalytic approach to access radical chemistry, which is harnessed by combining pharmaceutically relevant sulfonamides with an assortment of alkene fragments. Additionally, the sulfinate anion can be readily obtained, further broadening the options for sulfonamide functionalization. Mechanistic studies suggest that energy-transfer catalysis (EnT) is in operation.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, 1.5MB, Terms of use)
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- Publisher copy:
- 10.1021/acscatal.2c01442
Authors
- Publisher:
- American Chemical Society
- Journal:
- ACS Catalysis More from this journal
- Volume:
- 12
- Issue:
- 10
- Pages:
- 6060-6067
- Publication date:
- 2022-05-06
- Acceptance date:
- 2022-04-25
- DOI:
- EISSN:
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2155-5435
- Language:
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English
- Keywords:
- Pubs id:
-
1253547
- Local pid:
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pubs:1253547
- Deposit date:
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2022-04-26
Terms of use
- Copyright holder:
- Tilby et al.
- Copyright date:
- 2022
- Rights statement:
- Copyright © 2022 The Authors. Published by American Chemical Society. This is an open access article published under CC BY 4.0.
- Licence:
- CC Attribution (CC BY)
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