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ELTD1 activation induces an endothelial-EMT transition to a myofibroblast phenotype

Abstract:

ELTD1 is expressed in endothelial and vascular smooth muscle cells and has a role in angiogenesis. It has been classified as an adhesion GPCR, but as yet, no ligand has been identified and its function remains unknown. To establish its role, ELTD1 was overexpressed in endothelial cells. Expression and consequently ligand independent activation of ELTD1 results in endothelial-mesenchymal transistion (EndMT) with a loss of cell-cell contact, formation of stress fibres and mature focal adhesions...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3390/ijms222011293

Authors


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Role:
Author
ORCID:
0000-0002-0945-5496
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Role:
Author
ORCID:
0000-0001-8168-1538
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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Oxford college:
Lady Margaret Hall
Role:
Author
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Name:
British Heart Foundation
Grant:
FS/16/5/32054
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Name:
Oxfordshire Health Service Research Comm
Grant:
1358
Publisher:
MDPI
Journal:
International Journal of Molecular Sciences More from this journal
Volume:
22
Issue:
20
Article number:
11293
Publication date:
2021-10-19
Acceptance date:
2021-10-14
DOI:
EISSN:
1422-0067
ISSN:
1661-6596
Pmid:
34681953
Language:
English
Keywords:
Pubs id:
1207538
Local pid:
pubs:1207538
Deposit date:
2022-11-15

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