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A functional protein pore with a "retro" transmembrane domain.

Abstract:

Extended retro (reversed) peptide sequences have not previously been accommodated within functional proteins. Here, we show that the entire transmembrane portion of the beta-barrel of the pore-forming protein alpha-hemolysin can be formed by retrosequences comprising a total of 175 amino acid residues, 25 contributed by the central sequence of each subunit of the heptameric pore. The properties of wild-type and retro heptamers in planar bilayers are similar. The single-channel conductance of ...

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Publication status:
Published

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Publisher copy:
10.1110/ps.8.6.1257

Authors


Publisher:
Cambridge University Press
Journal:
Protein science : a publication of the Protein Society
Volume:
8
Issue:
6
Pages:
1257-1267
Publication date:
1999-06-05
DOI:
EISSN:
1469-896X
ISSN:
0961-8368
URN:
uuid:95ab9545-b474-4487-ab89-1dc0bfe1bdc5
Source identifiers:
52186
Local pid:
pubs:52186

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