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Solubilization of receptors for the novel Ca2+-mobilizing messenger, nicotinic acid adenine dinucleotide phosphate.

Abstract:

Nicotinic acid adenine dinucleotide phosphate (NAADP) is a potent Ca(2+) mobilizing agent in a variety of broken and intact cell preparations. In sea urchin egg homogenates, NAADP releases Ca(2+) independently of inositol trisphosphate or ryanodine receptor activation. Little, however, is known concerning the molecular target for NAADP. Here we report for the first time solubilization of NAADP receptors from sea urchin egg homogenates. Supernatant fractions, prepared following Triton X-100 tr...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m203224200

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology, BHF Centre of Research Excellence
Role:
Author
Journal:
The Journal of biological chemistry
Volume:
277
Issue:
46
Pages:
43717-43723
Publication date:
2002-11-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:959c659b-94ab-4511-8174-d04d77fbd7d3
Source identifiers:
106332
Local pid:
pubs:106332

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