- Abstract:
-
The genetic architecture of common traits, including the number, frequency, and effect sizes of inherited variants that contribute to individual risk, has been long debated. Genome-wide association studies have identified scores of common variants associated with type 2 diabetes, but in aggregate, these explain only a fraction of the heritability of this disease. Here, to test the hypothesis that lower-frequency variants explain much of the remainder, the GoT2D and T2D-GENES consortia perform...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted manuscript
- Files:
-
-
(pdf, 2.5mb)
-
- Publisher copy:
- 10.1038/nature18642
-
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- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Nature Journal website
- Volume:
- 536
- Issue:
- 7614
- Pages:
- 41-47
- Publication date:
- 2016-07-05
- Acceptance date:
- 2016-06-12
- DOI:
- EISSN:
-
1476-4687
- ISSN:
-
0028-0836
- Pubs id:
-
pubs:628233
- URN:
-
uri:955ea002-ffa6-4293-817c-f76d92226720
- UUID:
-
uuid:955ea002-ffa6-4293-817c-f76d92226720
- Local pid:
- pubs:628233
- Copyright holder:
- Macmillan Publishers Limited
- Copyright date:
- 2016
- Notes:
- © 2016 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.
Journal article
The genetic architecture of type 2 diabetes.
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