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Journal article

The genetic architecture of type 2 diabetes.

Abstract:

The genetic architecture of common traits, including the number, frequency, and effect sizes of inherited variants that contribute to individual risk, has been long debated. Genome-wide association studies have identified scores of common variants associated with type 2 diabetes, but in aggregate, these explain only a fraction of the heritability of this disease. Here, to test the hypothesis that lower-frequency variants explain much of the remainder, the GoT2D and T2D-GENES consortia perform...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1038/nature18642

Authors


Fuchsberger, C More by this author
Flannick, J More by this author
Teslovich, TM More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Human Genetics Wt Centre
Agarwala, V More by this author
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Journal website
Volume:
536
Issue:
7614
Pages:
41-47
Publication date:
2016-07-05
Acceptance date:
2016-06-12
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
Pubs id:
pubs:628233
URN:
uri:955ea002-ffa6-4293-817c-f76d92226720
UUID:
uuid:955ea002-ffa6-4293-817c-f76d92226720
Local pid:
pubs:628233

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