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The fecal metabolome as a functional readout of the gut microbiome

Abstract:

The human gut microbiome plays a key role in human health1, but 16S characterization lacks quantitative functional annotation2. The fecal metabolome provides a functional readout of microbial activity and can be used as an intermediate phenotype mediating host–microbiome interactions3. In this comprehensive description of the fecal metabolome, examining 1,116 metabolites from 786 individuals from a population-based twin study (TwinsUK), the fecal metabolome was found to be only modestly influ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1038/s41588-018-0135-7

Authors


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ORCID:
0000-0002-9693-1859
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Institution:
University of Oxford
Division:
Medical Sciences
Department:
NDORMS; Rheumatology
ORCID:
0000-0002-7891-6217
Kastenmüller, G More by this author
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ORCID:
0000-0002-2167-7470
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ORCID:
0000-0002-7052-9546
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Genetics Journal website
Volume:
50
Pages:
790-795
Publication date:
2018-05-28
Acceptance date:
2018-04-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
Pubs id:
pubs:904946
URN:
uri:9546048e-7101-4e51-b709-1526451585c9
UUID:
uuid:9546048e-7101-4e51-b709-1526451585c9
Local pid:
pubs:904946

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