A scaffold for X chromosome inactivation.

Journal article

X chromosome inactivation (XCI), the silencing of one of the two X chromosomes in XX female cells, equalises the dosage of X-linked genes relative to XY males. The process is mediated by the non-coding RNA X inactive specific transcript (Xist) that binds in cis and propagates along the inactive X chromosome elect, triggering chromosome-wide silencing. The mechanisms by which Xist RNA binds and spreads along the chromosome, and initiates Xist-mediated chromosome silencing remain poorly underst...

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Authors: Tattermusch, A; Brockdorff, N

• Publication status: Published
• Journal: Human genetics
• Volume: 130
• Issue: 2
• Pages: 247-253
• Publication date: 2011-08-01
• DOI: 10.1007/s00439-011-1027-4
• EISSN: 1432-1203
• ISSN: 0340-6717
• Language: English
• Keywords: Female; Chromosomes, Human, X; Matrix Attachment Region Binding Proteins; RNA, Untranslated; X Chromosome Inactivation; Heterogeneous-Nuclear Ribonucleoprotein U; RNA, Long Noncoding; Male; Models, Biological; Nuclear Matrix; Humans