Widespread distribution of binding sites for the novel Ca2+-mobilizing messenger, nicotinic acid adenine dinucleotide phosphate, in the brain.

Journal article

Nicotinic acid adenine dinucleotide phosphate (NAADP) is a potent Ca(2+)-mobilizing agent in invertebrate eggs that has recently been shown to be active in certain mammalian and plant systems. Little, however, is known concerning the properties of putative NAADP receptors. Here, for the first time, we report binding sites for NAADP in brain. In contrast to sea urchin egg homogenates, [(32)P]NAADP bound reversibly to multiple sites in brain membranes. The rank order of potency of NAADP, 2',3'-...

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Authors: Patel, S; Churchill, G; Sharp, T; Galione, A

• Publication status: Published
• Journal: Journal of biological chemistry
• Volume: 275
• Issue: 47
• Pages: 36495-36497
• Publication date: 2000-11-01
• DOI: 10.1074/jbc.c000458200
• EISSN: 1083-351X
• ISSN: 0021-9258
• Language: English
• Keywords: Rats, Sprague-Dawley; Male; Rats; Sea Urchins; Calcium; Cells, Cultured; Binding Sites; Signal Transduction; Animals; NADP