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Journal article

A motor function for the DEAD-box RNA helicase, Gemin3, in Drosophila.

Abstract:

The survival motor neuron (SMN) protein, the determining factor for spinal muscular atrophy (SMA), is complexed with a group of proteins in human cells. Gemin3 is the only RNA helicase in the SMN complex. Here, we report the identification of Drosophila melanogaster Gemin3 and investigate its function in vivo. Like in vertebrates, Gemin3 physically interacts with SMN in Drosophila. Loss of function of gemin3 results in lethality at larval and/or prepupal stages. Before they die, gemin3 mutant...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pgen.1000265

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Medical Research Council More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Genetics Journal website
Volume:
4
Issue:
11
Article number:
e1000265
Publication date:
2008-11-21
Acceptance date:
2008-10-16
DOI:
EISSN:
1553-7404
ISSN:
1553-7390
Source identifiers:
106254
Language:
English
Keywords:
Pubs id:
pubs:106254
UUID:
uuid:94d4b881-0100-4d04-b103-2478d91ba89c
Local pid:
pubs:106254
Deposit date:
2012-12-19

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