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Fetal hemoglobin is associated with peripheral oxygen saturation in sickle cell disease in Tanzania.

Abstract:

Fetal hemoglobin (HbF) and peripheral hemoglobin oxygen saturation (SpO2) both predict clinical severity in sickle cell disease (SCD), while reticulocytosis is associated with vasculopathy, but there are few data on mechanisms. HbF, SpO2 and routine clinical and laboratory measures were available in a Tanzanian cohort of 1175 SCD individuals aged≥5years and the association with SpO2 (as response variable transformed to a Poisson distribution) was assessed by negative binomial model with age a...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.ebiom.2017.08.006

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Publisher:
Elsevier Publisher's website
Journal:
EBioMedicine Journal website
Volume:
23
Pages:
146-149
Publication date:
2017-08-05
Acceptance date:
2017-08-05
DOI:
EISSN:
2352-3964
Pubs id:
pubs:726003
URN:
uri:949432ca-f7f6-437e-b229-98ff507ccc5b
UUID:
uuid:949432ca-f7f6-437e-b229-98ff507ccc5b
Local pid:
pubs:726003

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