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Successful targeting of the mouse cystic fibrosis transmembrane conductance regulator gene in embryonal stem cells.

Abstract:
We wish to construct a mouse model for the human inherited disease cystic fibrosis. We describe here the successful targeting in embryonal stem cells of the murine homologue (Cftr) of the cystic fibrosis transmembrane conductance regulator gene, as the first critical step towards this end. The targeting event precisely disrupts exon 10, the site of the major mutation in patients with cystic fibrosis. The targeted cells are pluripotent and competent to form chimaeras.

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Publisher copy:
10.1007/bf02513027

Authors


Dickinson, P More by this author
Clarke, AR More by this author
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Publisher:
Kluwer Academic Publishers
Journal:
Transgenic research
Volume:
1
Issue:
2
Pages:
101-105
Publication date:
1992-03-05
DOI:
EISSN:
1573-9368
ISSN:
0962-8819
URN:
uuid:94923638-b0e5-40b5-a1c3-e0cba2b1bde9
Source identifiers:
251641
Local pid:
pubs:251641

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