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On the proportion of cancer stem cells in a tumour

Abstract:
It is now generally accepted that cancers contain a sub-population, the cancer stem cells (CSCs), which initiate and drive a tumour’s growth. At least until recently it has been widely assumed that only a small proportion of the cells in a tumour are CSCs. Here we use a mathematical model, supported by experimental evidence, to show that such an assumption is unwarranted. We show that CSCs may comprise any possible proportion of the tumour, and that the higher the proportion the more aggressive the tumour is likely to be.

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M. D. Johnston More by this author
P. K. Maini More by this author
S. J. Chapman More by this author
C. M. Edwards More by this author
W. F. Bodmer More by this author
Publication date:
2010
URN:
uuid:947e9cb8-dcd6-41cc-bbdb-2649fbd01afb
Local pid:
oai:eprints.maths.ox.ac.uk:968

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