Journal article : Review
Recent advances in the synthesis of pyrroles
- Abstract:
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Pyrroles are the most prevalent heterocyclic compounds, which are present as the basic cores in many natural products, such as vitamin B12, bile pigments like bilirubin and biliverdin, the porphyrins of heme, chlorophyll, chlorins, bacteriochlorins, and porphyrinogens. The biological activities of compounds having pyrrole analogs include antimicrobial (antibacterial, antifungal), anti-cancer (anti-cytotoxic, antimitotic), anti-tumor, anti-hyperlipidemic, anti-depressant, anti-inflammatory, antihyperglycemic, antiproliferative, anti-HIV and anti-viral activities. Accordingly, significant attention has been paid to develop competent methods for the synthesis of pyrroles with improved yields in short times. This review gives an overview of different methods for the synthesis of pyrrole using easily available precursors using the following routes.
- Synthesis of monosubstituted pyrrole using 2,5-dimethoxyfuran
- Synthesis of pyrrole using dialkylacetylene dicarboxylate
-Synthesis of pyrroles using β-ketoester
-Synthesis of pyrrole using 1,2-dicarbonyl compounds
-Synthesis of pyrroles using 1,3-dicarbonyl compounds
-Synthesis of pyrroles using 1,3-dicarbonyl, amine, nitro and aldehyde group
-Synthesis of pyrroles using 1,4-dicarbonyl compound and amines
-Synthesis of pyrrole using enones
- Synthesis of pyrroles using moieties having acetylene groupv
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
-
-
(Preview, Accepted manuscript, pdf, 3.6MB, Terms of use)
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- Publisher copy:
- 10.2174/1385272824999200528125651
Authors
- Publisher:
- Bentham Science Publishers
- Journal:
- Current Organic Chemistry More from this journal
- Volume:
- 24
- Issue:
- 11
- Pages:
- 1196-1229
- Publication date:
- 2020-05-28
- Acceptance date:
- 2020-03-01
- DOI:
- EISSN:
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1875-5348
- ISSN:
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1385-2728
- Language:
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English
- Keywords:
- Subtype:
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Review
- Pubs id:
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1135172
- Local pid:
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pubs:1135172
- Deposit date:
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2020-12-03
- ARK identifier:
Terms of use
- Copyright holder:
- Bentham Science
- Copyright date:
- 2020
- Rights statement:
- © 2020 Bentham Science.
- Notes:
- This is the accepted manuscript version of the article. The final version is available online from Bentham Science Publishers at: https://doi.org/10.2174/1385272824999200528125651
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