Journal article
CLC-5 and KIF3B interact to facilitate CLC-5 plasma membrane expression, endocytosis, and microtubular transport: relevance to pathophysiology of Dent's disease.
- Abstract:
-
Renal tubular reabsorption is important for extracellular fluid homeostasis and much of this occurs via the receptor-mediated endocytic pathway. This pathway is disrupted in Dent's disease, an X-linked renal tubular disorder that is characterized by low-molecular-weight proteinuria, hypercalciuria, nephrolithiasis, and renal failure. Dent's disease is due to mutations of CLC-5, a chloride/proton antiporter, expressed in endosomes and apical membranes of renal tubules. Loss of CLC-5 function a...
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- Publication status:
- Published
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Bibliographic Details
- Journal:
- American journal of physiology. Renal physiology
- Volume:
- 298
- Issue:
- 2
- Pages:
- F365-F380
- Publication date:
- 2010-02-01
- DOI:
- EISSN:
-
1522-1466
- ISSN:
-
1931-857X
- Source identifiers:
-
17386
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:17386
- UUID:
-
uuid:946255ce-8d7d-4bcc-ac9e-ab6ed105cdb8
- Local pid:
- pubs:17386
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2010
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