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CLC-5 and KIF3B interact to facilitate CLC-5 plasma membrane expression, endocytosis, and microtubular transport: relevance to pathophysiology of Dent's disease.

Abstract:

Renal tubular reabsorption is important for extracellular fluid homeostasis and much of this occurs via the receptor-mediated endocytic pathway. This pathway is disrupted in Dent's disease, an X-linked renal tubular disorder that is characterized by low-molecular-weight proteinuria, hypercalciuria, nephrolithiasis, and renal failure. Dent's disease is due to mutations of CLC-5, a chloride/proton antiporter, expressed in endosomes and apical membranes of renal tubules. Loss of CLC-5 function a...

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Publication status:
Published

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Publisher copy:
10.1152/ajprenal.00038.2009

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Journal:
American journal of physiology. Renal physiology
Volume:
298
Issue:
2
Pages:
F365-F380
Publication date:
2010-02-05
DOI:
EISSN:
1522-1466
ISSN:
1931-857X
URN:
uuid:946255ce-8d7d-4bcc-ac9e-ab6ed105cdb8
Source identifiers:
17386
Local pid:
pubs:17386

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