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Pharmacological inhibition of LIM kinase stabilizes microtubules and inhibits neoplastic growth.

Abstract:

The emergence of tumor resistance to conventional microtubule-targeting drugs restricts their clinical use. Using a cell-based assay that recognizes microtubule polymerization status to screen for chemicals that interact with regulators of microtubule dynamics, we identified Pyr1, a cell permeable inhibitor of LIM kinase, which is the enzyme that phosphorylates and inactivates the actin-depolymerizing factor cofilin. Pyr1 reversibly stabilized microtubules, blocked actin microfilament dynamic...

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Publication status:
Published

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Authors


Prudent, R More by this author
Vassal-Stermann, E More by this author
Nguyen, CH More by this author
Martinez, A More by this author
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Journal:
Cancer research
Volume:
72
Issue:
17
Pages:
4429-4439
Publication date:
2012-09-05
DOI:
EISSN:
1538-7445
ISSN:
0008-5472
URN:
uuid:944df36e-f9c9-4eac-8109-566d0f7212a8
Source identifiers:
349806
Local pid:
pubs:349806

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