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Chapter 11. Mast cell localization within the airway smooth muscle: Relationship to airway hyperresponsiveness and other asthma phenotypes

Abstract:

Asthma is a condition characterized by variable airflow obstruction, airway hyperresponsiveness (AHR) and airway inflammation which is usually, but not invariably, eosinophilic. Current thoughts on the pathogenesis of asthma are focused on the idea that it is caused by an inappropriate response of the specific immune system to harmless antigens, particularly allergens such as cat dander and house dust mite, that result in Th2-mediated chronic inflammation. However, the relationship between in...

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Authors


Wardlaw, AJ More by this author
Bradding, P More by this author
Pavord, ID More by this author
Brightling, CE More by this author
Journal:
Clinical and Experimental Allergy Reviews
Volume:
4
Issue:
SUPPL. 2
Pages:
111-117
Publication date:
2004-12-05
DOI:
ISSN:
1472-9725
URN:
uuid:941d80ce-fdc8-4709-86b2-59ad8b2f0354
Source identifiers:
435429
Local pid:
pubs:435429

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