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Synthesis of the anti-trypanosomal agent (±)-hydroxyanthecotulide by Cr(ii)-catalysed allylation and Meyer-Schuster rearrangement.

Abstract:
The first synthesis of the bioactive sesquiterpene lactone hydroxyanthecotulide is achieved in 7 steps, involving a stereocontrolled Cr(ii)-catalysed reaction of 3-(bromomethyl)furan-2(5H)-one with enynal 9 and a mild Au(i)-catalysed Meyer-Schuster rearrangement.
Publication status:
Published

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Publisher copy:
10.1039/c2cc32283h

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author


Journal:
Chemical Communications More from this journal
Volume:
48
Issue:
51
Pages:
6349-6350
Publication date:
2012-05-01
DOI:
EISSN:
1364-548X
ISSN:
1359-7345


Language:
English
Pubs id:
pubs:332004
UUID:
uuid:939e07eb-819f-461c-b43a-a72f0fea4432
Local pid:
pubs:332004
Source identifiers:
332004
Deposit date:
2012-12-19

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