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Journal article

Prognostic implications of NOTCH1 and FBXW7 mutations in adults with T-cell acute lymphoblastic leukemia treated on the MRC UKALLXII/ECOG E2993 protocol.

Abstract:

PURPOSE: Notch pathway activation by mutations in either NOTCH1 and/or FBXW7 is one of the most common molecular events in T-cell acute lymphoblastic leukemia (T-ALL) and, in pediatric disease, predicts for favorable outcome. Their prognostic significance in adult T-ALL is unclear. We sought to evaluate the outcome according to mutation status of patients with adult T-ALL treated on the United Kingdom Acute Lymphoblastic Leukaemia XII (UKALLXII)/Eastern Cooperative Oncology Group (ECOG) E2993...

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Publication status:
Published

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Publisher copy:
10.1200/jco.2009.22.0996

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Journal:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Volume:
27
Issue:
26
Pages:
4352-4356
Publication date:
2009-09-05
DOI:
EISSN:
1527-7755
ISSN:
0732-183X
URN:
uuid:9370f69d-7f8e-47c7-8250-aefbc16ac8f1
Source identifiers:
66797
Local pid:
pubs:66797

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