Prognostic implications of NOTCH1 and FBXW7 mutations in adults with T-cell acute lymphoblastic leukemia treated on the MRC UKALLXII/ECOG E2993 protocol.

Journal article

PURPOSE: Notch pathway activation by mutations in either NOTCH1 and/or FBXW7 is one of the most common molecular events in T-cell acute lymphoblastic leukemia (T-ALL) and, in pediatric disease, predicts for favorable outcome. Their prognostic significance in adult T-ALL is unclear. We sought to evaluate the outcome according to mutation status of patients with adult T-ALL treated on the United Kingdom Acute Lymphoblastic Leukaemia XII (UKALLXII)/Eastern Cooperative Oncology Group (ECOG) E2993...

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Authors: Mansour, MR; Sulis, M; Duke, V; Foroni, L; Jenkinson, S

• Publication status: Published
• Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology
• Volume: 27
• Issue: 26
• Pages: 4352-4356
• Publication date: 2009-09-01
• DOI: 10.1200/jco.2009.22.0996
• EISSN: 1527-7755
• ISSN: 0732-183X
• Language: English
• Keywords: Genotype; Ubiquitin-Protein Ligases; Treatment Outcome; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; F-Box Proteins; Gene Frequency; Male; Prognosis; Young Adult; Cell Cycle Proteins; Chromatography, High Pressure Liquid; Humans; Female; Adolescent; Middle Aged; Receptor, Notch1; Disease-Free Survival; Adult; Multivariate Analysis; Mutation; Follow-Up Studies; Great Britain; DNA Mutational Analysis