Immune response to vaccination in people with psychotic disorders relative to healthy controls: prospective study of SARS-CoV-2 vaccination

Journal article

This prospective study examines the immune response to SARS-CoV-2 vaccination in patients with psychotic disorders compared with healthy volunteers. Participants were recruited naturalistically as part of the UK's COVID-19 vaccination programme. Prior to receiving their first COVID-19 vaccine, blood samples were provided by participants to examine anti-SARS-CoV-2 immunoglobulins (IgG) at baseline, followed by a repeat assay 1 month after receiving their first vaccine to assess vaccine response. The increase of IgG levels from baseline to 1 month post-vaccination was significantly lower in patients compared with controls, supporting evidence of impaired vaccine response in people with psychotic disorders. When excluding patients treated with clozapine from the analysis, this difference was no longer significant, suggesting that effects may be particularly marked in people taking clozapine

Authors: O'Brien, O; Arumuham, A; Mizuno, Y; Baxter, L; Lobo, M

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Cambridge University Press
• Journal: BJPsych Open
• Volume: 10
• Issue: 2
• Pages: e49-e49
• Article number: e49
• Publication date: 2024-02-16
• DOI: 10.1192/bjo.2024.10
• EISSN: 2056-4724
• ISSN: 2056-4724
• Language: English
• Keywords: Schizophrenia (object-oriented programming); Prospective cohort study; Disease; Clozapine; Vaccination; Medicine; Immune system; Coronavirus disease 2019 (COVID-19); Internal medicine; Immunology; Psychiatry