Recovery of effective hiv-specific cd4+ t-cell activity following antiretroviral therapy in paediatric infection requires sustained suppression of viraemia

Journal article

Background

The success of increasing access to antiretroviral therapy (ART) in paediatric HIV infection prompts the question of the potential for eradication of HIV infection in this age group. ‘Shock-and-kill’ HIV cure approaches, currently in development, may depend upon an effective antiviral T-cell response to eradicate virus-infected cells.

Method

We here investigate the ability of HIV-infected children receiving ART from early childhood (median 24 months’ age) to generate effective HIV-specific CD4þ and CD8þ T-cell immune responses thatwould facilitate future immune-based cure therapies.

Results

Initial analysis of ART-naive HIV-infected children demonstrated that maintenance of normal-for-age absolute CD4þ T-cell counts was strongly linked to high IL-2 production and polyfunctional HIV-specific CD4þ T-cell responses (P<0.0001 in each case). Low viral load was, similarly, strongly associated with markedly low IFN-g and high IL-2 HIV-specific CD4þ T-cell responses (P<0.0001). In children receiving ART, establishment of this immune profile (high IL-2 and low IFN-g HIV-specific T-cell production) was strongly related to the duration of viraemic suppression. Failure to suppress viraemia on ART, and even the successful suppression of viraemia interrupted by the occurrence of transient viraemia of more than 1000 HIV copies/ml, was associated with an immune profile of high IFN-g and low IL-2 HIV-specific T-cell responses and low polyfunctionality.

Conclusion

These data are consistent with recovery of functional CD4þ T-cell responses in ART-treated children, in contrast to relative lack of CD4þ T-cell function recovery described in ART-treated adults. However, the challenges of achieving longterm suppression of viraemia in ART-treated children through adolescence remain daunting.

Authors: Adland, E; Mori, L; Laker, L; Csala, A; Muenchhoff, M

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Lippincott, Williams and Wilkins
• Journal: AIDS
• Volume: 32
• Issue: 11
• Pages: 1413–1422
• Publication date: 2018-05-03
• Acceptance date: 2018-04-10
• DOI: 10.1097/qad.0000000000001844
• EISSN: 1473-5571
• ISSN: 0269-9370
• Pmid: 29734220
• Language: English
• Keywords: immune reconstitution; T-cell polyfunctionality; antiretroviral therapy; adolescence; HIV; paediatrics; CD4þ T cell