CVOT Summit Report 2025: advances along the cardiovascular–kidney–metabolic disease continuum

Schnell, O; Agarwal, A; Azizi, M; Ballwieser, D; Barnard-Kelly, K; Battelino, T; Blüher, M; Bugianesi, E; Cebrian, A; Ceriello, A; Choudhary, P; Danne, T; Dayan, CM; Del Prato, S; Eckel, RH; Fioretto, P; Garvey, T; Green, JB; Heerspink, HJL; Holman, RR; Itzhak, B; Jacob, S; Jhund, PS; Ji, L; Judge, PK

Journal article : Comment

CVOT Summit Report 2025: advances along the cardiovascular–kidney–metabolic disease continuum

Abstract:: The 11th Cardiovascular Outcome Trial (CVOT) Summit: Congress on Cardiovascular, Kidney, and Metabolic Outcomes was held virtually on November 20–21, 2025. The Summit provided a multidisciplinary forum to review and discuss recent outcome trials investigating emerging pharmacological therapies targeting diseases of the cardiovascular–kidney–metabolic (CKM) continuum. This report highlights the unique developments of 2025 discussed during the Summit, including the first head-to-head CVOT (SURPASS-CVOT), the growing evidence base for combination therapies across the disease spectrum, new insights into the inflammatory component of the CKM syndrome, and relevant policy developments. The first part of this report summarizes pioneering clinical trials addressing combination therapy with finerenone and empagliflozin (CONFIDENCE), the oral glucagon-like peptide-1 (GLP-1) receptor agonists orforglipron (ATTAIN-1), and the aldosterone synthase inhibitor (ASI) baxdrostat (BaxHTN). The second part presents recent guideline and policy developments discussed by experts in endocrinology, diabetology, cardiology, nephrology, hepatology, and general practice. In addition, advances in medical technology, particularly in continuous glucose and ketone monitoring, are highlighted, as well as emerging therapies for diseases of the CKM continuum. These include pharmacological agents for a broad spectrum of metabolic disorders such as metabolic liver disease and type 1 Diabetes (T1D) alongside emphasis on the importance of early detection and innovative treatment strategies. The 12th Cardiovascular Outcome Trial Summit will be held virtually on 19–20 November 2026 (http://www.cvot.org).

Publication status:: Published

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APA Style

Schnell, O., Agarwal, A., Azizi, M., Ballwieser, D., Barnard-Kelly, K., Battelino, T., Blüher, M., Bugianesi, E., Cebrian, A., Ceriello, A., Choudhary, P., Danne, T., Dayan, C. M., Del Prato, S., Eckel, R. H., Fioretto, P., Garvey, T., Green, J. B., Heerspink, H. J. L., … Judge, P. K. (2026). CVOT Summit Report 2025: advances along the cardiovascular–kidney–metabolic disease continuum. Cardiovascular Diabetology, 25(1).

MLA Style

Schnell, O, et al. “CVOT Summit Report 2025: Advances along the Cardiovascular–Kidney–Metabolic Disease Continuum.” Cardiovascular Diabetology, vol. 25, no. 1, 2026.

Chicago Style

Schnell, O, A Agarwal, M Azizi, et al. 2026. “CVOT Summit Report 2025: Advances along the Cardiovascular–Kidney–Metabolic Disease Continuum.” Cardiovascular Diabetology 25 (1).
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