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Quantification of Plasmodium ex vivo drug susceptibility by flow cytometry.

Abstract:

The emergence and spread of multidrug-resistant Plasmodium falciparum and Plasmodium vivax highlights the need for objective measures of ex vivo drug susceptibility. Flow cytometry (FC) has potential to provide a robust and rapid quantification of ex vivo parasite growth.Field isolates from Papua, Indonesia, underwent ex vivo drug susceptibility testing against chloroquine, amodiaquine, piperaquine, mefloquine, and artesunate. A single nucleic acid stain (i.e., hydroethidine (HE) for P. falci...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/s12936-015-0940-8

Authors


Wirjanata, G More by this author
Handayuni, I More by this author
Prayoga, P More by this author
Apriyanti, D More by this author
Chalfein, F More by this author
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Funding agency for:
Price, RN
Publisher:
BioMed Central Publisher's website
Journal:
Malaria journal Journal website
Volume:
14
Issue:
1
Pages:
417
Publication date:
2015
DOI:
EISSN:
1475-2875
ISSN:
1475-2875
URN:
uuid:93311cc4-66b6-46e3-82bf-ecec3cd3e3e7
Source identifiers:
572945
Local pid:
pubs:572945

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