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Cluster-randomized test-negative design trials: A novel and efficient method to assess the efficacy of community-level Dengue interventions

Abstract:

Cluster-randomized controlled trials are the gold standard for assessing efficacy of community-level interventions, such as vector-control strategies against dengue. We describe a novel cluster-randomized trial methodology with a test-negative design (CR-TND), which offers advantages over traditional approaches. This method uses outcome-based sampling of patients presenting with a syndrome consistent with the disease of interest, who are subsequently classified as test-positive cases or test-...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/aje/kwy099

Authors


Anders, KL More by this author
Cutcher, Z More by this author
Kleinschmidt, I More by this author
Donnelly, CA More by this author
Ferguson, NM More by this author
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Tahija Family Foundation More from this funder
Wellcome Trust More from this funder
Publisher:
Oxford University Press Publisher's website
Journal:
American Journal of Epidemiology Journal website
Volume:
187
Issue:
9
Pages:
2021-2028
Publication date:
2018-05-07
Acceptance date:
2018-04-27
DOI:
EISSN:
1476-6256
ISSN:
0002-9262
Pubs id:
pubs:847990
URN:
uri:931f1db0-124f-4a85-8354-c68e15070365
UUID:
uuid:931f1db0-124f-4a85-8354-c68e15070365
Local pid:
pubs:847990

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