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Journal article

Reference values for body composition and associations with blood pressure in Kenyan adults aged ≥50 years old

Abstract:
Objectives: To develop age and sex-specific centile reference curves for fat free mass (FFM) and fat mass (FM) adjusted for height in an adult Kenyan population and to investigate the association between FM, FFM and blood pressure (BP). Methods: Measures of body composition from bioimpedance analyses and BP were collected in 1,995 participants aged ≥50y in Nakuru County, Kenya. Reference curves were produced using the LMS method. Multivariable linear regression models were used to test the cross-sectional association between body composition indexes and BP. Results: The age and sex-specific reference curves for body composition (FMI and FFMI) confirm that FFMI is lower in both men and women with increasing age. FMI declines with age in women while among men the decline starts after 70 years. FFM was higher in men (47.4 ± 7.2 kg) than in women (38.8 ± 5.5 kg), while FM was lower in men (17.3 ± 8.1 kg) than in women (24.4 ± 10.2 kg). FMI, FFMI and BMI were all positively associated with systolic and diastolic BP, and after adjusting for body weight, FFMI remained positively associated with systolic BP and the FMI remained positively associated with diastolic BP. There was no evidence to suggest that FMI and FFMI were superior to measurement of BMI alone. Conclusion: These body composition reference curves provide normative data on body composition for older adults in Kenya. Further research should consider the prospective associations with health, including frailty-related outcomes.
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41430-018-0177-z

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Primary Care; Primary Care Health Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Primary Care Health Sciences
Role:
Author
ORCID:
0000-0002-7536-922X
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Primary Care; Primary Care Health Sciences
Role:
Author


More from this funder
Funding agency for:
Piernas Sanchez, C
Jebb, S
Grant:
CollaborationforLeadershipinApplied HealthResearch
CareOxfordatOxfordHealthNHSFoundationTrust
CollaborationforLeadershipinApplied HealthResearch
CareOxfordatOxfordHealthNHSFoundationTrust


Publisher:
Springer Nature
Journal:
European Journal of Clinical Nutrition More from this journal
Volume:
73
Pages:
558–565
Publication date:
2018-05-15
Acceptance date:
2018-03-28
DOI:
ISSN:
1476-5640


Keywords:
Pubs id:
pubs:833227
UUID:
uuid:931ecd4b-40c6-41c8-89ac-52f6b82337b6
Local pid:
pubs:833227
Source identifiers:
833227
Deposit date:
2018-04-04

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