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ATP sensitivity of the ATP-sensitive K+ channel in intact and permeabilized pancreatic beta-cells.

Abstract:

ATP-sensitive K(+) channels (K(ATP) channels) couple cell metabolism to electrical activity and thereby to physiological processes such as hormone secretion, muscle contraction, and neuronal activity. However, the mechanism by which metabolism regulates K(ATP) channel activity, and the channel sensitivity to inhibition by ATP in its native environment, remain controversial. Here, we used alpha-toxin to permeabilize single pancreatic beta-cells and measure K(ATP) channel ATP sensitivity. We sh...

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Publication status:
Published

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Publisher copy:
10.2337/db06-0360

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
Journal:
Diabetes
Volume:
55
Issue:
9
Pages:
2446-2454
Publication date:
2006-09-05
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
URN:
uuid:92d3b013-75d9-4254-97b8-1807f21af818
Source identifiers:
113607
Local pid:
pubs:113607

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