The epicardium signals the way towards heart regeneration.

Journal article

Abstract:: From historical studies of developing chick hearts to recent advances in regenerative injury models, the epicardium has arisen as a key player in heart genesis and repair. The epicardium provides paracrine signals to nurture growth of the developing heart from mid-gestation, and epicardium-derived cells act as progenitors of numerous cardiac cell types. Interference with either process is terminal for heart development and embryogenesis. In adulthood, the dormant epicardium reinstates an embryonic gene programme in response to injury. Furthermore, injury-induced epicardial signalling is essential for heart regeneration in zebrafish. Given these critical roles in development, injury response and heart regeneration, the application of epicardial signals following adult heart injury could offer therapeutic strategies for the treatment of ischaemic heart disease and heart failure.

Files:: The epicardium signals the way towards heart regeneration.pdf

(Preview, Version of record, pdf, 546.2KB, Terms of use)

Language:: English
Keywords:: Humans

Pericardium

Animals

Signal Transduction

Regeneration

Heart

Myocardial Ischemia
Pubs id:: pubs:470351
UUID:: uuid:92cf06b3-7b11-4d39-9376-5331e546e498
Local pid:: pubs:470351
Source identifiers:: 470351
Deposit date:: 2015-01-16
ARK identifier:: ark:/29072/ora_92cf06b37b114d3993765331e546e498

Copyright holder:: Masters and Riley
Notes:: publisher: Elsevier
articletitle: The epicardium signals the way towards heart regeneration
journaltitle: Stem Cell Research
articlelink: http://dx.doi.org/10.1016/j.scr.2014.04.007
content_type: article
copyright: Copyright © 2014 Published by Elsevier B.V. Copyright © 2014 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND
license (http://creativecommons.org/licenses/by-nc-nd/3.0/).

If you are the owner of this record, you can report an update to it here: Report update to this record