Oxygen free radical scavenger enzyme polymorphisms in systemic sclerosis.

Journal article

We performed a case-control study of polymorphisms of glutathione S-transferase (GST) isoenzymes and manganese superoxide dismutase (MnSOD) in black South Africans with systemic sclerosis (SSc). The frequency of the GSTM1*B phenotype was significantly decreased in the overall SSc group compared with controls (OR=0.19, p(corr)<.05), implying a possible protective effect against development of the disease. There was also a trend toward increased MnSODAla allele and phenotype frequencies in the diffuse cutaneous SSc subset compared with controls (OR=2.11 and 3.15, respectively, p(corr)<.1). Our findings provide new data on the distribution of GST and MnSOD polymorphisms in healthy Africans and further evidence that genetic factors may have a contributory role to play in predisposing to oxidative stress in SSc.

Authors: Tikly, M; Marshall, SE; Haldar, N; Gulumian, M; Wordsworth, P

• Publication status: Published
• Journal: Free radical biology and medicine
• Volume: 36
• Issue: 11
• Pages: 1403-1407
• Publication date: 2004-06-01
• DOI: 10.1016/j.freeradbiomed.2004.02.079
• EISSN: 1873-4596
• ISSN: 0891-5849
• Language: English
• Keywords: Superoxide Dismutase; Alleles; Male; Polymorphism, Genetic; Phenotype; Scleroderma, Systemic; Free Radical Scavengers; Humans; Female; Oxygen; Case-Control Studies; Glutathione Transferase