Journal article
Serum Contactin-1 in CIDP: a cross-sectional study
- Abstract:
-
Objective To investigate whether serum levels of contactin-1, a paranodal protein, correlate with paranodal injury as seen in patients with CIDP with antibodies targeting the paranodal region.
Methods Serum contactin-1 levels were measured in 187 patients with CIDP and 222 healthy controls. Paranodal antibodies were investigated in all patients.
Results Serum contactin-1 levels were lower in patients (N = 41) with paranodal antibodies compared with patients (N = 146) without paranodal antibodies (p < 0.01) and showed good discrimination between these groups (area under the curve 0.84; 95% CI: 0.76–0.93).
Conclusions These findings suggest that serum contactin-1 levels have the potential to serve as a possible diagnostic biomarker of paranodal injury in CIDP.
Classification of Evidence This study provides class II evidence that serum contactin-1 levels can discriminate between patients with CIDP with or without paranodal antibodies with a sensitivity of 71% (95% CI: 56%–85%) and a specificity of 97% (95% CI: 83%–100%).
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Preview, Version of record, pdf, 323.5KB, Terms of use)
-
- Publisher copy:
- 10.1212/nxi.0000000000001040
Authors
- Publisher:
- American Academy of Neurology
- Journal:
- Neurology: Neuroimmunology and Neuroinflammation More from this journal
- Volume:
- 8
- Issue:
- 5
- Article number:
- e1040
- Publication date:
- 2021-07-20
- Acceptance date:
- 2021-05-20
- DOI:
- EISSN:
-
2332-7812
- Pmid:
-
34285092
- Language:
-
English
- Keywords:
- Pubs id:
-
1187530
- Local pid:
-
pubs:1187530
- Deposit date:
-
2022-08-15
Terms of use
- Copyright holder:
- Wieske et al.
- Copyright date:
- 2021
- Rights statement:
- ©2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND), which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
If you are the owner of this record, you can report an update to it here: Report update to this record