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Journal article

Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry.

Abstract:

Protein synthesis in mammalian cells requires initiation factor eIF3, an approximately 800-kDa protein complex that plays a central role in binding of initiator methionyl-tRNA and mRNA to the 40 S ribosomal subunit to form the 48 S initiation complex. The eIF3 complex also prevents premature association of the 40 and 60 S ribosomal subunits and interacts with other initiation factors involved in start codon selection. The molecular mechanisms by which eIF3 exerts these functions are poorly un...

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Publication status:
Published

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Publisher copy:
10.1074/mcp.m600399-mcp200

Authors


Fraser, CS More by this author
Videler, H More by this author
Mayeur, GL More by this author
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Journal:
Molecular and cellular proteomics : MCP
Volume:
6
Issue:
7
Pages:
1135-1146
Publication date:
2007-07-05
DOI:
EISSN:
1535-9484
ISSN:
1535-9476
URN:
uuid:92b95c47-a005-4e73-8aad-94d4d81e4fc1
Source identifiers:
59413
Local pid:
pubs:59413

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