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Photoinduced multicomponent synthesis of α-silyloxy acrylamides, an unexplored class of silyl enol ethers

Abstract:

The photoinduced, multicomponent reaction of α-diazoketones, silanols, and isocyanides affords α-silyloxy acrylamides, formally derived from α-keto amides. The presence of a secondary amido group makes classic preparative methods for silyl enol ethers unfeasible in this case, while the mild conditions required by this photochemical approach allow their synthesis in good yields; moreover, the general structure can be easily modified by varying each component of the multicomponent reaction. Fin...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1021/acs.orglett.8b00009

Authors


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Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry; Organic Chemistry
Role:
Author
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Role:
Author
ORCID:
0000-0001-5149-2963
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Publisher:
American Chemical Society Publisher's website
Journal:
Organic Letters Journal website
Volume:
20
Issue:
4
Pages:
1098-1101
Publication date:
2018-01-30
Acceptance date:
2018-01-25
DOI:
EISSN:
1523-7052
ISSN:
1523-7060
Pubs id:
pubs:827773
URN:
uri:92a916ce-4650-49b0-b57c-3a6a90e50a8f
UUID:
uuid:92a916ce-4650-49b0-b57c-3a6a90e50a8f
Local pid:
pubs:827773
Language:
English

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