Journal article
Parallel roles of neuroinflammation in feline and human epilepsies
- Abstract:
- Autoimmune encephalitis refers to a group of disorders characterised by a non-infectious encephalitis, often with prominent seizures and surface neuronal autoantibodies. AE is an important cause of new-onset refractory status epilepticus in humans and is frequently responsive to immunotherapies including corticosteroids, plasma exchange, intravenous immunoglobulin G and rituximab. Recent research suggests that parallel autoantibodies can be detected in non-human mammalian species. The best documented example is leucine-rich glioma-inactivated 1 (LGI1)-antibodies in domestic cats with limbic encephalitis (LE). In this review, we discuss the role of neuroinflammation and autoantibodies in human and feline epilepsy and LE.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 5.9MB, Terms of use)
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- Publisher copy:
- 10.1016/j.tvjl.2022.105912
Authors
- Publisher:
- Elsevier
- Journal:
- Veterinary Journal More from this journal
- Volume:
- 290
- Article number:
- 105912
- Publication date:
- 2022-10-06
- Acceptance date:
- 2022-10-03
- DOI:
- EISSN:
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1532-2971
- ISSN:
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1090-0233
- Language:
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English
- Keywords:
- Pubs id:
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2069985
- Local pid:
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pubs:2069985
- Deposit date:
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2025-02-07
Terms of use
- Copyright holder:
- Binks et al.
- Copyright date:
- 2022
- Rights statement:
- © 2022 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
- Notes:
- For the purpose of Open Access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission.
- Licence:
- CC Attribution (CC BY)
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