Alarmins: awaiting a clinical response.

Journal article

Alarmins are endogenous molecules that are constitutively available and released upon tissue damage and activate the immune system. Current evidence indicates that uncontrolled and excessive release of alarmins contributes to the dysregulated processes seen in many inflammatory and autoimmune conditions, as well as tumorigenesis and cancer spread. Conversely, alarmins have also been found to play a major role in the orchestration of tissue homeostasis, including repair and remodeling in the heart, skin, and nervous system. Here, we provide an update and overview on alarmins, highlighting the areas that may benefit from this clinical translation.

Authors: Chan, J; Roth, J; Oppenheim, J; Tracey, K; Vogl, T

• Publication status: Published
• Journal: Journal of clinical investigation
• Volume: 122
• Issue: 8
• Pages: 2711-2719
• Publication date: 2012-08-01
• DOI: 10.1172/jci62423
• EISSN: 1558-8238
• ISSN: 0021-9738
• Language: English
• Keywords: Inflammation Mediators; Systemic Inflammatory Response Syndrome; Regenerative Medicine; Immunity, Innate; Biological Markers; Adaptive Immunity; Sepsis; Neoplasms; Signal Transduction; Animals; Inflammation; Humans; Autoimmune Diseases