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A transmission-virulence evolutionary trade-off explains attenuation of HIV-1 in Uganda

Abstract:

Evolutionary theory hypothesizes that intermediate virulence maximizes pathogen fitness as a result of a trade-off between virulence and transmission, but empirical evidence remains scarce. We bridge this gap using data from a large and long-standing HIV-1 prospective cohort, in Uganda. We use an epidemiological-evolutionary model parameterised with this data to derive evolutionary predictions based on analysis and detailed individual-based simulations. We robustly predict stabilising selecti...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Files:
Publisher copy:
10.7554/eLife.20492

Authors


Grabowski, MK More by this author
Herbeck, J More by this author
Nalugoda, F More by this author
Serwadda, D More by this author
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National Institutes of Health More from this funder
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Grant:
R01 Al 29314, R01 AI34826, UO1 AI11171-01-02
John Snow Inc. More from this funder
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Publisher:
eLife Sciences Publications Publisher's website
Journal:
eLife Journal website
Publication date:
2016-11-05
Acceptance date:
2016-11-04
DOI:
EISSN:
2050-084X
ISSN:
2050-084X
Pubs id:
pubs:657345
URN:
uri:924fafec-81eb-405b-ba26-b01deb06f7ae
UUID:
uuid:924fafec-81eb-405b-ba26-b01deb06f7ae
Local pid:
pubs:657345

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