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Integrating mass spectrometry with MD simulations reveals the role of lipids in Na(+)/H(+) antiporters

Abstract:

Na(+)/H(+) antiporters are found in all kingdoms of life and exhibit catalysis rates that are among the fastest of all known secondary-active transporters. Here we combine ion mobility mass spectrometry and molecular dynamics simulations to study the conformational stability and lipid-binding properties of the Na(+)/H(+) exchanger NapA from Thermus thermophilus and compare this to the prototypical antiporter NhaA from Escherichia coli and the human homologue NHA2. We find that NapA and NHA2, ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/ncomms13993

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More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Physical & Theoretical Chem
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Physical & Theoretical Chem
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Physical & Theoretical Chem
Role:
Author
Publisher:
Springer Nature
Journal:
Nature Communications More from this journal
Volume:
8
Pages:
13993
Publication date:
2017-01-10
Acceptance date:
2016-11-18
DOI:
ISSN:
2041-1723
Language:
English
Keywords:
Pubs id:
pubs:671447
UUID:
uuid:92379d27-cb36-4c95-bb46-ab0cd50782b2
Local pid:
pubs:671447
Source identifiers:
671447
Deposit date:
2017-01-31

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