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Mechanisms of the effects of nicorandil in the isolated rat heart during ischemia and reperfusion: a 31P-nuclear magnetic resonance study.

Abstract:

Nicorandil (SG75) is a potent K+-channel activator with an additional nitro moiety. In the present study we investigated the potential mechanisms (K+-channel activation and nitric oxide [NO] release) for the effects of nicorandil on isolated perfused rat hearts during total global ischemia using 31P-nuclear magnetic resonance. After a 10-min control perfusion, hearts were subjected to treatment with nicorandil-containing (100, 300, or 1000 microM) buffer for 10 min, 15 min of total global isc...

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Publication status:
Published

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Publisher copy:
10.1081/jcmr-100108589

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Journal:
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
Volume:
3
Issue:
4
Pages:
349-360
Publication date:
2001-01-01
DOI:
EISSN:
1532-429X
ISSN:
1097-6647
URN:
uuid:922e7d12-d421-4bed-adfe-584004e4f91c
Source identifiers:
124775
Local pid:
pubs:124775

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