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Minimal in vivo efficacy of iminosugars in a lethal ebola virus guinea pig model

Abstract:

The antiviral properties of iminosugars have been reported previously in vitro and in small animal models against Ebola virus (EBOV); however, their effects have not been tested in larger animal models such as guinea pigs. We tested the iminosugars N-butyl-deoxynojirimycin (NB-DNJ) and N-(9- methoxynonyl)-1deoxynojirimycin (MON-DNJ) for safety in uninfected animals, and for antiviral efficacy in animals infected with a lethal dose of guinea pig adapted EBOV. 1850 mg/kg/day NB-DNJ and 120...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0167018

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Department:
Oxford, MSD, Biochemistry
Dowall, SD More by this author
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS ONE Journal website
Volume:
11
Issue:
11
Pages:
Article: e0167018
Publication date:
2016
Acceptance date:
2016-11-08
DOI:
ISSN:
1932-6203
Pubs id:
pubs:657781
URN:
uri:9226c7dc-e6d8-443b-a687-f0fb555fc9cb
UUID:
uuid:9226c7dc-e6d8-443b-a687-f0fb555fc9cb
Local pid:
pubs:657781

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