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Recapitulation of developmental mechanisms to revascularise the ischemic heart

Abstract:

Restoring blood flow after myocardial infarction (MI) is essential for survival of existing and newly regenerated tissue. Endogenous vascular repair processes are deployed following injury, but are poorly understood. We sought to determine whether developmental mechanisms of coronary vessel formation are intrinsically reactivated in the adult mouse post-MI. Using pulse-chase genetic lineage tracing, we establish that de novo vessel formation constitutes a significant component of the neovascu...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1172/jci.insight.96800

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
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Grant:
RM/13/3/30159; Research Fellowships and Studentships
Publisher:
American Society for Clinical Investigation Publisher's website
Journal:
JCI Insight Journal website
Volume:
2
Issue:
22
Pages:
96800
Publication date:
2017-11-16
Acceptance date:
2017-10-11
DOI:
ISSN:
2379-3708
Pubs id:
pubs:737073
URN:
uri:9223b818-60b5-435b-865c-c7b3487ce632
UUID:
uuid:9223b818-60b5-435b-865c-c7b3487ce632
Local pid:
pubs:737073

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