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Glucose analogue inhibitors of glycogen phosphorylase: the design of potential drugs for diabetes.

Abstract:

The T-state crystal structure of the glucose-phosphorylase b complex has been used as a model for the design of glucose analogue inhibitors that may be effective in the regulation of blood glucose levels. Modeling studies indicated room for additional atoms attached at the C1-beta position of glucose and some scope for additional atoms at the C1-alpha position. Kinetic parameters were determined for alpha-D-glucose: Ki = 1.7 mM, Hill coefficient n = 1.5, and alpha (synergism with caffeine) = ...

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Publication status:
Published

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Publisher copy:
10.1021/bi00106a006

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Role:
Author
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Journal:
Biochemistry
Volume:
30
Issue:
42
Pages:
10101-10116
Publication date:
1991-10-05
DOI:
EISSN:
1520-4995
ISSN:
0006-2960
URN:
uuid:91f9edb4-7ae0-42b0-8dac-67e5f0bee5f5
Source identifiers:
43644
Local pid:
pubs:43644

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