Journal article icon

Journal article

Glucose analogue inhibitors of glycogen phosphorylase: the design of potential drugs for diabetes.

Abstract:

The T-state crystal structure of the glucose-phosphorylase b complex has been used as a model for the design of glucose analogue inhibitors that may be effective in the regulation of blood glucose levels. Modeling studies indicated room for additional atoms attached at the C1-beta position of glucose and some scope for additional atoms at the C1-alpha position. Kinetic parameters were determined for alpha-D-glucose: Ki = 1.7 mM, Hill coefficient n = 1.5, and alpha (synergism with caffeine) = ...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1021/bi00106a006

Authors


More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
Expand authors...
Journal:
Biochemistry
Volume:
30
Issue:
42
Pages:
10101-10116
Publication date:
1991-10-01
DOI:
EISSN:
1520-4995
ISSN:
0006-2960
Source identifiers:
43644
Language:
English
Keywords:
Pubs id:
pubs:43644
UUID:
uuid:91f9edb4-7ae0-42b0-8dac-67e5f0bee5f5
Local pid:
pubs:43644
Deposit date:
2012-12-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP