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MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system.

Abstract:

The high level of 5-hydroxymethylcytosine (5hmC) present in neuronal genomes suggests that mechanisms interpreting 5hmC in the CNS may differ from those present in embryonic stem cells. Here, we present quantitative, genome-wide analysis of 5hmC, 5-methylcytosine (5mC), and gene expression in differentiated CNS cell types in vivo. We report that 5hmC is enriched in active genes and that, surprisingly, strong depletion of 5mC is observed over these regions. The contribution of these epigenetic...

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Publication status:
Published

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Publisher copy:
10.1016/j.cell.2012.11.022

Authors


Mellén, M More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Ludwig Institute
Journal:
Cell
Volume:
151
Issue:
7
Pages:
1417-1430
Publication date:
2012-12-05
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
URN:
uuid:91e5d1d6-cb3f-4ed9-945f-c61e7a540f31
Source identifiers:
369862
Local pid:
pubs:369862

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