Evaluation of the Efficacy of ChAd63-MVA Vectored Vaccines Expressing Circumsporozoite Protein and ME-TRAP Against Controlled Human Malaria Infection in Malaria-Naive Individuals.

Journal article

BACKGROUND:  Circumsporozoite protein (CS) is the antigenic target for RTS,S, the most advanced malaria vaccine to date. Heterologous prime-boost with the viral vectors simian adenovirus 63 (ChAd63)-modified vaccinia virus Ankara (MVA) is the most potent inducer of T-cells in humans, demonstrating significant efficacy when expressing the preerythrocytic antigen insert multiple epitope-thrombospondin-related adhesion protein (ME-TRAP). We hypothesized that ChAd63-MVA containing CS may result i...

Expand abstract

Authors: Hodgson, S; Ewer, K; Bliss, C; Edwards, N; Rampling, T

• Journal: Journal of infectious diseases
• Publication date: 2014-10-01
• DOI: 10.1093/infdis/jiu579
• EISSN: 1537-6613
• ISSN: 0022-1899
• Language: English
• Keywords: CHMI; vaccine; ME-TRAP; malaria; CS; MVA; P. falciparum; ChAd63