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A novel mutation (F227L) arises in the reverse transcriptase of human immunodeficiency virus type 1 on dose-escalating treatment of HIV type 1-infected cell cultures with the nonnucleoside reverse transcriptase inhibitor thiocarboxanilide UC-781.

Abstract:

Treatment of wild-type human immunodeficiency virus [HIV-1(IIIB)]-infected cell cultures with the thiocarboxanilide UC-781 under low selective pressure (i.e., 0.01 microg/ml) resulted in the emergence of V106A RT mutant virus. On increasing drug concentrations (stepwise up to 30 microg/ml) the virus retained the V106A RT mutation but acquired the novel F227L mutation in the RT genome in addition to the L100I, K1O1I, and Y181C mutations. This multiple-mutant virus proved highly resistant to vi...

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Publication status:
Published

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Publisher copy:
10.1089/aid.1998.14.255

Authors


Balzarini, J More by this author
Pelemans, H More by this author
De Clercq, E More by this author
Journal:
AIDS research and human retroviruses
Volume:
14
Issue:
3
Pages:
255-260
Publication date:
1998-02-05
DOI:
EISSN:
1931-8405
ISSN:
0889-2229
URN:
uuid:91a72474-f00d-4ebd-9e4b-94d2238e8583
Source identifiers:
26720
Local pid:
pubs:26720

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