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The role of 5-hydroxymethylcytosine in aging and Alzheimer's disease: current status and prospects for future studies.

Abstract:

Epigenetic modifications have been proposed to underlie age-related dysfunction and associated disorders. 5- hydroxymethylcytosine (5-hmC) is a newly described epigenetic modification. It is generated by the oxidation of 5- methylcytosine (5-mC) by the ten-eleven translocation (TET) family of enzymes. Various studies have shown that 5-hmC is present in high levels in the brain. Its lower affinity to methyl-binding proteins as compared to 5-mC suggests that it might have a different role in th...

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Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Role:
Author
Journal:
Current Alzheimer research
Volume:
9
Issue:
5
Pages:
545-549
Publication date:
2012-06-05
EISSN:
1875-5828
ISSN:
1567-2050
URN:
uuid:916adb92-b6c6-4b5b-a04a-aa8aaddd18df
Source identifiers:
456146
Local pid:
pubs:456146

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