Journal article
The role of 5-hydroxymethylcytosine in aging and Alzheimer's disease: current status and prospects for future studies.
- Abstract:
-
Epigenetic modifications have been proposed to underlie age-related dysfunction and associated disorders. 5- hydroxymethylcytosine (5-hmC) is a newly described epigenetic modification. It is generated by the oxidation of 5- methylcytosine (5-mC) by the ten-eleven translocation (TET) family of enzymes. Various studies have shown that 5-hmC is present in high levels in the brain. Its lower affinity to methyl-binding proteins as compared to 5-mC suggests that it might have a different role in th...
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Bibliographic Details
- Journal:
- Current Alzheimer research
- Volume:
- 9
- Issue:
- 5
- Pages:
- 545-549
- Publication date:
- 2012-06-01
- EISSN:
-
1875-5828
- ISSN:
-
1567-2050
- Source identifiers:
-
456146
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:456146
- UUID:
-
uuid:916adb92-b6c6-4b5b-a04a-aa8aaddd18df
- Local pid:
- pubs:456146
- Deposit date:
- 2014-05-12
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- Copyright date:
- 2012
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