The role of 5-hydroxymethylcytosine in aging and Alzheimer's disease: current status and prospects for future studies.

van den Hove, DL; Chouliaras, L; Rutten, BP

Abstract:

Epigenetic modifications have been proposed to underlie age-related dysfunction and associated disorders. 5- hydroxymethylcytosine (5-hmC) is a newly described epigenetic modification. It is generated by the oxidation of 5- methylcytosine (5-mC) by the ten-eleven translocation (TET) family of enzymes. Various studies have shown that 5-hmC is present in high levels in the brain. Its lower affinity to methyl-binding proteins as compared to 5-mC suggests that it might have a different role in th...

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APA Style

van den Hove, D. L., Chouliaras, L., & Rutten, B. P. (2012). The role of 5-hydroxymethylcytosine in aging and Alzheimer's disease: current status and prospects for future studies. Current Alzheimer Research, 9(5), 545–549.

MLA Style

van den Hove, D. L., et al. “The Role of 5-Hydroxymethylcytosine in Aging and Alzheimer's Disease: Current Status and Prospects for Future Studies.” Current Alzheimer Research, vol. 9, no. 5, 2012, pp. 545–49.

Chicago Style

Hove, DL van den, L Chouliaras, and BP Rutten. 2012. “The Role of 5-Hydroxymethylcytosine in Aging and Alzheimer's Disease: Current Status and Prospects for Future Studies.” Current Alzheimer Research 9 (5): 545–49.
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