Journal article
Rab regulation by GEFs and GAPs during membrane traffic
- Abstract:
- Rab GTPases and their regulatory proteins play a crucial role in vesicle-mediated membrane trafficking. During vesicle membrane tethering Rab GTPases are activated by GEFs (guanine nucleotide exchange factors) and then inactivated by GAPs (GTPase activating proteins). Recent evidence shows that in addition to activating and inactivating Rab GTPases, both Rab GEFs and GAPs directly contribute to membrane tethering events during vesicle traffic. Other studies have extended the range of processes, in which Rabs function, and revealed roles for Rabs and their GAPs in the regulation of autophagy. Here, we will discuss these advances and the emerging relationship between the domain architectures of Rab GEFs and vesicle coat protein complexes linked with GTPases of the Sar, ARF and Arl families in animal cells.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Preview, Accepted manuscript, pdf, 388.0KB, Terms of use)
-
- Publisher copy:
- 10.1016/j.ceb.2019.03.004
Authors
- Publisher:
- Elsevier
- Journal:
- Current Opinion in Cell Biology More from this journal
- Volume:
- 59
- Pages:
- 34-39
- Publication date:
- 2019-04-10
- Acceptance date:
- 2019-03-06
- DOI:
- EISSN:
-
1879-0410
- ISSN:
-
0955-0674
- Pmid:
-
30981180
- Language:
-
English
- Keywords:
- Pubs id:
-
pubs:992580
- UUID:
-
uuid:91574e98-56e1-43a7-8d2f-d181c8cb0ace
- Local pid:
-
pubs:992580
- Source identifiers:
-
992580
- Deposit date:
-
2019-06-11
- ARK identifier:
Terms of use
- Copyright date:
- 2019
- Rights statement:
- Copyright © 2019 Published by Elsevier Ltd.
- Notes:
- This is the accepted manuscript version of the article. The final version is available online from Elsevier at https://doi.org/10.1016/j.ceb.2019.03.004
If you are the owner of this record, you can report an update to it here: Report update to this record