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The nsp9 replicase protein of SARS-coronavirus, structure and functional insights.

Abstract:

As part of a high-throughput structural analysis of SARS-coronavirus (SARS-CoV) proteins, we have solved the structure of the non-structural protein 9 (nsp9). This protein, encoded by ORF1a, has no designated function but is most likely involved with viral RNA synthesis. The protein comprises a single beta-barrel with a fold previously unseen in single domain proteins. The fold superficially resembles an OB-fold with a C-terminal extension and is related to both of the two subdomains of the S...

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Publication status:
Published

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Authors


Sainsbury, S More by this author
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Journal:
Structure (London, England : 1993)
Volume:
12
Issue:
2
Pages:
341-353
Publication date:
2004-02-05
DOI:
EISSN:
1878-4186
ISSN:
0969-2126
URN:
uuid:914a2c99-9f92-423c-bea0-26c03758752e
Source identifiers:
18032
Local pid:
pubs:18032

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