- Abstract:
-
3-Hydroxy-3-methylglutaryl coenzyme A (CoA) synthase (HMGCS) catalyzes the condensation of acetyl-CoA and acetoacetyl-CoA into 3-hydroxy-3-methylglutaryl CoA. It is ubiquitous across the phylogenetic tree and is broadly classified into three classes. The prokaryotic isoform is essential in Gram-positive bacteria for isoprenoid synthesis via the mevalonate pathway. The eukaryotic cytosolic isoform also participates in the mevalonate pathway but its end product is cholesterol. Mammals also cont...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/j.jmb.2010.03.034
-
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- Journal:
- Journal of molecular biology
- Volume:
- 398
- Issue:
- 4
- Pages:
- 497-506
- Publication date:
- 2010-05-05
- DOI:
- EISSN:
-
1089-8638
- ISSN:
-
0022-2836
- URN:
-
uuid:9149e285-5708-4792-b970-e29a98bb9762
- Source identifiers:
-
108813
- Local pid:
- pubs:108813
- Copyright date:
- 2010
Journal article
Crystal structures of human HMG-CoA synthase isoforms provide insights into inherited ketogenesis disorders and inhibitor design.
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