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Crystal structures of human HMG-CoA synthase isoforms provide insights into inherited ketogenesis disorders and inhibitor design.

Abstract:

3-Hydroxy-3-methylglutaryl coenzyme A (CoA) synthase (HMGCS) catalyzes the condensation of acetyl-CoA and acetoacetyl-CoA into 3-hydroxy-3-methylglutaryl CoA. It is ubiquitous across the phylogenetic tree and is broadly classified into three classes. The prokaryotic isoform is essential in Gram-positive bacteria for isoprenoid synthesis via the mevalonate pathway. The eukaryotic cytosolic isoform also participates in the mevalonate pathway but its end product is cholesterol. Mammals also cont...

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Publication status:
Published

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Publisher copy:
10.1016/j.jmb.2010.03.034

Authors


Journal:
Journal of molecular biology
Volume:
398
Issue:
4
Pages:
497-506
Publication date:
2010-05-05
DOI:
EISSN:
1089-8638
ISSN:
0022-2836
URN:
uuid:9149e285-5708-4792-b970-e29a98bb9762
Source identifiers:
108813
Local pid:
pubs:108813

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